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PD Dr. Burkhard Schütz

Philipps-Universität Marburg, Fachbereich Medizin

Institut für Anatomie und Zellbiologie

Robert-Koch-Straße 8

35037 Marburg

Phone: +49 6421 – 2864030

Fax: +49 6421 – 2868965

Email: schuetzb@staff.uni-marburg.de

Homepage

Schütz

Research focus
Amyotrophic lateral sclerosis: neurodegeneration, pathogenic involvement of astrocytes, microglia, lymphocytes, SOD1 mouse model, role of neuropeptides CGRP, PACAP
Neurodevelopment: cholinergic gene locus, specification of neurotransmitter phenotypes in sympathetic neurons, sweat gland innervation
Chemical coding of autonomic neurons in humans and rodents
Non-neuronal acetylcholine: cholinergic phenotype of brush cells and keratinocytes


Techniques

- Immunohistochemistry

- in situ hybridization

- qRT-PCR

- mouse behavioral tests (motor function, pain)

- Western blot

- Animal models (transgenic) of amyotrophic lateral sclerosis, EGFP-expression in cholinergic cells

- Neuropeptide and neuropeptide receptor knockout mouse models

 

Publications (since 2008)


1. Ringer C, Büning L-S, Schäfer MK-H, Eiden LE, Weihe E, Schütz B (2013) PACAP signaling exerts opposing effects on neuroprotection and neuroinflammation during disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Neurobiol. Dis. 54:32-42.

2. Fuchs A, Kutterer S, Mühling T, Duda J, Schütz B, Liss B, Keller BU, Roeper J (2013) Selective mitochondrial Ca2+ uptake deficit in disease endstage vulnerable motoneurons of the SOD1G93A mouse model of amyotrophic lateral sclerosis. J. Physiol. 591:2723-45.

3. Krasteva G, Hartmann P, Papadakis T, Bodenbenner M, Wessels L, Weihe E, Schütz B, Langheinrich A, Chubanov V, Gudermann T, Ibanez-Tallon I, Kummer W (2012) Cholinergic chemosensory cells in the auditory tube. Histochem. Cell Biol. 137:483-497.

4. Ringer C, Weihe E, Schütz B (2012) Calcitonin gene-related peptide expression levels predict motor neuron vulnerability in the superoxide dismutase 1-G93A mouse model of amyotrophic lateral sclerosis. Neurobiol. Dis. 45:547-554.

5. Krasteva G, Canning B, Hartmann P, Veres T, Papadakis T, Mühlfeld C, Schliecker K, Tallini Y, Braun A, Hackstein H, Baal N, Weihe E, Schütz B, Kotlikoff M, Ibanez-Tallon I, Kummer W (2011) Cholinergic chemosensory cells in the trachea regulate breathing. Proc. Natl. Acad. Sci. USA 108(23):9478-9483.

6. Fuchs A, Ringer C, Bilkei-Gorzo A, Weihe E, Roeper J, Schütz B (2010) Downregulation of the potassium chloride cotransporter KCC2 in vulnerable motoneurons in the SOD1-G93A mouse model of amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 69(10): 1057-1070.

7. Ringer C, Weihe E, Schütz B (2009) Pre-symptomatic alterations in subcellular ßCGRP distribution in motor neurons precede astrogliosis in ALS mice. Neurobiol. Dis. 35:286-295.

8. Schütz B, von Engelhardt J, Gördes M, Schäfer MK-H, Eiden LE, Monyer H, Weihe E (2008) Sweat gland innervation is pioneered by sympathetic neurons expressing a cholinergic/noradrenergic co-phenotype in the mouse. Neuroscience 156: 310-318.


 
   

Zuletzt aktualisiert: 22.05.2013 · Busses

 
 
 
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