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SEPT: Side Effect Prevention Training for Nocebo Effects -
Optimizing Expectations for Side Effect Prevention and Better Quality of Life of Breast Cancer Patients Undergoing Endocrine Therapy

Principals Investigator

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Prof. Dr. Yvonne Nestoriuc
University Hamburg
Contact
Prof. Dr. Winfried Rief


Prof. Dr. Winfried Rief


Prof. Dr. Ute-Susann Albert
Department of Gynecology, Philipps-University, Marburg

Co-Researcher



Dipl.-Psych. Franziska Schuricht
Contact
Dipl.-Psych. P. v. Blankenburg

Dipl.-Psych. Pia von Blanckenburg
Contact

Funding

Transregional DFG Research Unit, subproject of the DFG research unit (FOR 1328): Expectation and conditioning as basic processes of the placebo and nocebo response: From neurobiology to clinical applications.

Cooperation

Breast Centre of the Department of Gynecology, Gynecological Endocrinology and Oncology at University Hospital Marburg in Germany (Head: Prof. U.-S. Albert)

Project Outline

Our research team Psychooncology examines how to provide best psychotherapeutic support for breast cancer patients after surgery. We focus on endocrine therapy of hormone-receptor positive breast cancer usually prescribed for 5 years of daily medication. Endocrine treatment works by lowering the bodily estrogen level, and has been proven to reduce risk of breast cancer recurrence by up to 50%. Besides the protective effect, a lot patients report suffering from considerable side effects especially within the first months of treatment. In a pilot study examining more than 100 breast cancer patients, we found a positive correlation between the amount of experienced side effects and the expectations before start with endocrine therapy. Those patients expecting to suffer from more symptoms in higher intensity subsequently reported a higher amount of symptoms. This finding points to the relevance of the nocebo effect in endocrine treatment. By means of a side effect prevention program specifically designed by our team, we aim to prevent the occurrence of nocebo- side effects and to improve quality of life by optimizing treatment expectations.

Keywords:

Publications

Journal articles
von Blanckenburg, P., Seifart, U., Conrad, N., Exner, C., Rief, W. & Nestoriuc, Y. (submitted). Life goals, depression and quality of life in cancer patients during rehabilitation.

Bookchapter
Schuricht, F. & Nestoriuc, Y. (in press). Placebo and Nocebo Effects in Oncology. In B. Carr & J. Steel (Eds). Psychological Aspects of Cancer Treatment and Coping. New York: Springer press.

Published Abstracts
von Blanckenburg, P., Schuricht, F., Albert, U.-S., Rief, W. & Nestoriuc, Y. (2012). Side effect prevention training- A program to enhance breast cancer patients´ quality of life during adjuvant endocrine therapy. International Journal of Behavioral Medicine. 19 (Suppl 1), 170

von Blanckenburg, P., Bodenbenner, M., Conrad, N., Rief, W., Exner, C. & Seifart, U. (2012). Life goals, depression and quality of life in cancer patients. Journal of Cancer Research and Clinical Oncology, 138 (Suppl 1), 77.

von Blanckenburg, P., Schuricht, F., Albert, U.-S., Rief, W. & Nestoriuc, Y. (2011). Illness Representations, Quality of life and Fatigue in Breast Cancer Patients treated with Adjuvant Endocrine Therapy. Preliminary Results of a Prospective Study. Verhaltenstherapie, 21 (Suppl 1), 38.

Nestoriuc, Y., Schuricht, F., Blanckenburg, P. v., Rief, W. & Albert, U.S. (2012). Communicating side effects by informing about possible benefits and harms: Effects on breast cancer patients’ satisfaction, knowledge and expectations. Journal of Cancer Research and Clinical Oncology, 138, (Suppl 1), 77.

Nestoriuc, Y., Schuricht, F., Blanckenburg, P. v., Albert, U.S. & Rief, W. (2011). Der Einfluss von Erwartungen auf den Behandlungsverlauf der Antihormonellen Therapie bei Brustkrebs-Patientinnen. Verhaltenstherapie, 21 (Suppl 1), 17.

Schuricht, F., von Blanckenburg, P., Albert, U.-S. Rief, W., & Nestoriuc, Y. (2011). Information about the Side Effects of Adjuvant Endocrine Therapy. Effects on Patients‘ Expectations. Verhaltenstherapie, 21 (Suppl 1), 38.

Schuricht, F., von Blanckenburg, P., Albert, U.-S. Rief, W., & Nestoriuc, Y. (2012). Expected symptom coping and quality of life in breast cancer patients receiving endocrine therapy. International Journal of Behavioral Medicine. 19 (Suppl 1), 170

Internet Links

Gynecological Endocrinology and Oncology at University Hospital Marburg in Germany

Zuletzt aktualisiert: 26.02.2013 · keilda

 
 
 
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