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Univ.-Prof.  Dr. med. Carsten Konrad  

Department of Psychiatry, Section for Cognitive Neuropsychiatry, University Hospital Marburg,

Rudolf Bultmann Str. 9, D-35033 Marburg, Germany

Phone: +49 6421 58 65622; Fax: +49 6421 58 68939

Email: carsten.konrad@med.uni-marburg.de

 

Research focus
The main focus of the research group is the exploration of the neurobiology and therapeutic mechanisms in affective disorders. Affective disorders are characterized by mood disturbances such as depressive-inhibited or a manic-agitated mood. Emotional as well as cognitive brain-functions are investigated using emotion-processing, aversive-conditioning, working-memory and longterm-memory tasks. Executive functions are investigated using the go-nogo, flanker, and stroop paradigm. Neuroanatomically, the limbic system with amygdala and hippocampus as well as the medial prefrontal cortex (anterior cingulate cortex) are in the focus of research. Based on the endophenotype approach, genetic influences on brain functions detected by MRI or EEG are considered besides classic neuropsychological and psychiatric testing (imaging genetics).
Therapeutic options are investigated as part of national multicenter studies, e.g. the application of the Cognitive Behavioural Analysis System of Psychotherapy (CBASP) is evaluated and Cognitive Behavioral Therapy (CBT) in panic disorders is assessed in a national multi-centric project for psychotherapy research.

Techniques

-    Functional Magnetic Resonance Imaging (FMRI)

-    Structural Magnetic Resonance Imaging (MRI)

-    Electroencephalography (EEG)

-    Imaging Genetics

-    Laboratory investigations (e.g. cortisol)

-    Neuropsychological testing

-    Psychiatric diagnostic testing

 

Publications (10 selected Publications since 2007)

1. Beste C, Domschke K, Falkenstein M, Konrad C (2010) Differential modulations of response control processes by 5-HT1A gene variation. Neuroimage, 50(2):764-71

2. Beste C, Domschke K, Kolev V, Yordanova J, Baffa A, Falkenstein M, Konrad C (2010) Functional 5-HT1a receptor polymorphism selectively modulates error-specific subprocesses of performance monitoring. Hum Brain Mapp, 31(4):621-30

3. Beste C, Kolev V, Yordanova J, Domschke K, Falkenstein M, Baune BT, Konrad C (2010) The role of the BDNF Val66Met polymorphism for the synchronization of error-specific neural networks. J Neurosci,  30(32):10727-33.

4. Huster RJ, Westerhausen R, Pantev C, Konrad C (2010) The role of the cingulate cortex as neural generator of the N200 and P300 in a tactile response inhibition task. Hum Brain Mapp, 31(8):1260-71

5. Konrad C*, Suslow T* (*equal contribution), Kugel H, Rumstadt D, Zwitserlood P, Schöning S, Ohrmann P, Bauer J, Pyka M, Kersting A, Arolt V, Heindel W, Dannlowski U (2010) Automatic mood-congruent amygdala responses to masked facial expressions in major depression. Biol Psych, 67(2):155-60

6. Konrad C*, Dannlowski U* (*equal contribution), Kugel H, Zwitserlood P, Domschke K, Schöning S, Ohrmann P, Bauer J, Pyka M, Hohoff C, Zhang W, Baune BT, Heindel W, Arolt V, Suslow T (2010) Emotion specific modulation of automatic amygdala responses by 5-HTTLPR genotype. Neuroimage, 53(3):893-8

7. Konrad C, Geburek AJ, Rist F, Blumenroth H, Fischer B, Husstedt I, Arolt V, Schiffbauer H, Lohmann H (2010) Long-term cognitive and emotional consequences of mild traumatic brain injury. Psychol Med, 22:1-15.

8. Pyka M, Burgmer M, Lenzen T, Pioch R, Dannlowski U, Pfleiderer B, Ewert AW, Heuft G, Arolt V, Konrad C (2011) Brain correlates of hypnotic paralysis - a resting-state fMRI study. Neuroimage 56(4):2173-82.

9. Schöning S, Zwitserlood P, Engelien A, Behnken A, Kugel H, Schiffbauer H, Lipina K, Pachur C, Kersting A, Dannlowski U, Baune BT, Zwanzger P, Reker T, Heindel W, Arolt V, Konrad C (2009) Working-Memory fMRI Reveals Cingulate Hyperactivation in Euthymic Major Depression. Hum Brain Mapp, 30(9):2746-56

10.  Sehlmeyer C, Dannlowski  U, Schöning S, Kugel H, Pyka M, Pfleiderer B, Zwitserlood P, Schiffbauer H, Heindel W, Arolt V, Konrad C (2011) Neural correlates of trait anxiety in fear extinction. Psychol Med 41(4):789-98.

 


 

 

Zuletzt aktualisiert: 03.05.2013 · Busses

 
 
 
Fb. 04 - Psychologie

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