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Prof. Dr. Richard Dodel  

Philipps-Universität Marburg, Fachbereich Medizin, Klinik für Neurologie

Baldingerstraße 35043 Marburg

Phone: +49 6421 – 5866251

Fax: +49 6421 – 5865474

Email: dodel@med.uni-marburg.de

http://www.ukgm.de/ugm_2/deu/umr_neu/index.html

http://www.therapieforschung-neurologie.eu


 

 
Prof. Dr. Richard Dodel


Research focus

Inflammatory mechanisms of plaque deposition in Alzheimer’s disease and other neurodegenerative disorders; the role of naturally occurring autoantibodies in health and neurological disorders; aggregation; target identification and validation for novel neuroprotective stategies (in vitro, in vivo).


Techniques

- Cell cultures of primary neurons and microglia

- protein isolation and purification

- standard methods of molecular cloning

- molecular biology and protein biochemistry

- SPR technology

- MSD

- ELISA technique

- Animal models (transgenic) of Alzheimer’s disease

- Behavioural lab

 

Publications (10 selected Publications since 2007)

1. Besong-Agbo D, Wolf E, Jessen F, Oechsner M, Hametner E, Poewe W, Reindl M, Oertel WH, Noelker C, Bacher M, Dodel R (2013) Naturally occurring α-synuclein autoantibody levels are lower in patients with Parkinson disease. Neurology. 80(2):169-75.

2. Mengel D, Röskam S, Neff F, Balakrishnan K, Deuster O, Gold M, Oertel WH, Bacher M, Bach JP, Dodel R. Naturally occurring autoantibodies interfere with β-amyloid metabolism and improve cognition in a transgenic mouse model of Alzheimer's disease 24 h after single treatment. Transl Psychiatry. 2013 Mar 5;3:e236. doi: 10.1038/tp.2012.151

3. Dodel R, Rominger A, Bartenstein P, Barkhof F, Blennow K, Förster S, Winter Y, Bach JP, Popp J, Alferink J, Wiltfang J, Buerger K, Otto M, Antuono P, Jacoby M, Richter R, Stevens J, Melamed I, Goldstein J, Haag S, Wietek S, Farlow M, Jessen (2013)  Intravenous immunoglobulin for treatment of mild-tomoderate Alzheimer’s disease: a phase 2, randomised, double-blind, placebo-controlled, dose-finding trial. Lancet Neurology. 12(3):233-43.

4. Noelker C, Morel L, Lescot T, Osterloh A, Alvarez-Fischer D, Breloer M, Henze C, Depboylu C, Skrzydelski D, Michel PP, Dodel RC, Lu L, Hirsch EC, Hunot S, Hartmann A. Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease. Sci Rep. 2013 Mar 6;3:1393

5. Wei X, Roettger Y, Tan B, He Y, Dodel R, Hampel H, Wei G, Haney J, Gu H, Johnstone BH, Liu J, Farlow MR, Du Y (2012) Human anti-prion antibodies block prion peptide fibril formation and neurotoxicity. J Biol Chem. 287(16):12858-66.

6. Gold M, Pul R, Bach JP, Stangel M, Dodel R (2012) Pathogenic and physiological autoantibodies in the central nervous system. Immunol Rev. 248(1):68-86. (Review)

7. Wei X, Roettger Y, Tan B, He Y, Dodel R, Hampel H, Wei G, Haney J, Gu H, Johnstone BH, Liu J, Farlow MR, Du Y (2012) Human anti-prion antibodies block prion peptide fibril formation and neurotoxicity. J Biol Chem. 287(16):12858-66.

8. Fontanilla CV, Ma Z, Wei X, Klotsche J, Zhao L, Wisniowski P, Dodel RC, Farlow MR, Oertel WH, Du Y (2011) Caffeic acid phenethyl ester prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration. Neuroscience 188:135-41

9. Dodel R, Balakrishnan B, Keyvani K, Deuster O, Neff F, Andrei-Selmer LC, Röskam S, Balzer-Geldsetzer M, Oertel WH, Du Y, Bacher M (2011) Naturally Occurring Autoantibodies against beta-Amyloid: Their Role in Alzheimer's Disease. J Neurosci 31(15):5847-54

10. Ernst A, Buerger K, Hartmann O, Dodel R, Noelker C, Sommer N, Schwarz M, Koehrle J, Bergmann A, Hampel H (2010) Midregional Proenkephalin A and N-terminal Protachykinin A are decreased in the cerebrospinal fluid of patients with dementia disorders and acute neuroinflammation. J Neuroimmunol. 221(1-2):62-7.

 

Zuletzt aktualisiert: 03.05.2013 · Busses

 
 
 
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