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Internet-based prevention of major depression

Principal Investigators

Foto Prof. Dr. Matthias Berking

Prof. Dr. Matthias Berking

David Daniel Ebert

Dr. Dirk Lehr (Leuphana Universität Lüneburg)


Claudia Buntrock


European Union


Innovationsinkubator Leuphana University Lüneburg
Philipps-Universität Marburg
VU Universität Amsterdam

Project Outline

Theoretical background: Major depression (MDD) is associated with a considerable loss of quality of life, increased mortality rates, and enormous economic costs. However, only one third of disease burden attributed to major depression could be averted with currently available evidence-based treatments. Preventive interventions might be capable of contributing to a reduction in disease burden. The aim of this study is, therefore, to evaluate a new approach to prevention of MDD, i.e. Internet-based cognitive behavioural therapy.
Methods: In a randomised controlled trial, a sample of 420 adults with subthreshold depression (CES-D > 16 < 28) will be randomised to receive either a guided self-help Internet-based intervention (GET.ON Mood) or psychoeducation only. The primary outcome is time to onset of MDD assessed at 12 months follow-up with the SCID/DSM-IV section for mood disorders. An economic evaluation using a societal perspective will be conducted.

Keywords: Prevention of Major Depression, Internet-based therapy, Internet-based health training

Internet Links

Adults suffering from subthreshold depression and who are interested in participating in the study can gather information about the internet-based training and apply for participation on the research website

Last modified: 02.05.2013 · keilda

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